Stroke

  • Condition

A cardiovascular accident or stroke is one of the most debilitating conditions with great impact to the health department and to the families of stroke sufferers. The mechanisms involved in the scenario of a stroke patient is the presence of injury to the brain tissue due to a disruption in blood circulation that could be a cause of a blood clog or a rupture of the blood vessel. This causes nutrient and oxygen alterations and there is cellular arrest with an accumulation of toxic substances such the initial inflammatory response.

Mesenchymal stem cells are being used in clinical research. The mechanisms by which they may improve patients outcomes are by reducing or controlling the local inflammatory response and releasing growth factors that help promote new blood vessel formation.

Lee and collaborators followed up with stroke patients for four years after receiving or not intravenous infusion of mesenchymal stem cells with a decrease in mortality in the treated group compared with the control group.

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References

  • Bhasin A, Srivastava P, Mohanty S, Bhatia R, Kumaran S, Bose S. Stem cell therapy: A clinical trial of stroke. Clinical Neurology and Neurosurgery 2013;115:1003-1008.
  • Díez-Tejedor E, Gutiérrez-Fernández M, Martínez-Sánchez P, et al. Reparative Therapy for Acute Ischemic Stroke with Allogeneic Mesenchymal Stem Cells from Adipose Tissue: A Safety Assessment. Journal of Stroke and Cerebrovascular Disease 2014;23(10):2694-2700.
  • Lee JS, Hong JM, Moon GJ, Lee PH, Ahn YH, Bang OY. A long-Term Follow-Up Study of Intravenous Autologous Mesenchymal Stem Cell Transplantation in Patients With Ischemic Stroke. Stem Cells 2010;28:1099-1106.
  • Savotz SI, MIsra V, Kasam M, Juneja H, Cox CS, Alderman S, et al. Intravenous Autologous Bone Marrow Mononuclear Cells for Ischemic Stroke. ANn Neurol 2011;70:59-69.

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