About Stem Cells

  • Cell Therapy

The Importance of Stem Cells

Stem cells have the remarkable potential to develop into many different cell types in the body throughout one’s lifespan. Many tissues serve as an internal repair system; dividing essentially without limit to replenish other cells in a living person. When a stem cell divides, each new duplicate has the potential to either remain in that state or to become another type of cell with specialized functions, such as muscle, red blood, or a brain cell.
Stem cells are distinguished from other cell types by three important characteristics:

  • Capable of self-renewal by dividing into stem cells alike
  • Differentiate into daughter cells that can commit to a cell line or organ
  • Persist throughout life even after long periods of being dormant

Stem cells are fundamental tools in regenerative medicine. By enhancing the body’s regenerative processes, this field specializes in pursuing, replacing, and repairing cells, tissues or organs. Stem cells are of medical and scientific interest due to their unique properties.

Mainly:

  1. Having the potential to divide and develop into many different cell types
  2. Not aging and may reproduce indefinitely

Adult Stem Cells

Adult stem cells are found throughout the human body during one’s lifetime. They are already somewhat specialized, meaning they can only differentiate or become a limited number of cell types. These stem cells are dubbed multipotent or pluripotent, depending on how many cell types they may develop into.

Adult stem cells are found in multiple parts of the body, most prominently within the bone marrow, intestines, umbilical cord, some nervous tissues, testicles, dental pulp, hair follicles and the endometrium. In conjunction with neighboring cells and depending on the body´s environment, they aid in repairing and regenerating damaged cells and tissues, a product of the body’s daily and normal strain. In simple terms, they are responsible for helping our bodies recover from everyday wear. These cells constitute an entirely functional and inherent element of self-repair.

Adult stem cells are more conveniently manipulated and harvested in contrast to embryonic stem cells which are found to be dangerously more powerful. SCs are considered pluripotent, which is almost any cell in the body, making it a true challenge to control their fate once they are administered.

Depending on the treatment´s approach, they can be collected through a biopsy, cultured and expanded in a lab and reintroduced into the body. The most exemplary and common application of adult stem cells is during a bone marrow transplant.

Stemedica’s Adult Stem Cells

Stemedica is a laboratory located in San Diego California with Good Manufacturing Practices, monitored by the FDA and with a license from the California Food and Drug Branch.

Since 2005, Stemedica has become a global biopharmaceutical company led by prominent scientists, leading clinicians, and medical, biotechnological and pharmaceutical experts. Stemedica produces mesenchymal stem cells (MSCs) with a patented technology specifically used for research and clinical studies. With this technology, they were able to create a master cell bank from a single bone marrow extraction, commonly known as allogeneic stem cells. From this single donation, Stemedica is able to get approximately ten million treatments versus traditional technologies’ fifty to one hundred treatments. This guarantees that the stem cells will be adept at maintaining and repairing tissue, having the same level of quality, potency, viability, completely traceable and safe. To further verify this, numerous bone marrow samples were researched and narrowed down to the top one hundred. After which, different sets of tests were conducted searching not only for safety, genetic abnormalities, and viruses but also measuring the cells’ ability to differentiate into bone, cartilage, and muscle cells, just to name a few. Finally, one mesenchymal adult stem cell, derived from bone marrow tissue, was selected as the most versatile in differentiating between the cells tested in a body.

Presently, one of our associated institutions utilizes both cells, mesenchymal and neural adult stem cells and is in consistent communication and compliance with Stemedica regarding their FDA-regulated stem cell products and clinical trial therapies.

Stem cell types

Mesenchymal stem cells

Mesenchymal Stem Cells (MSC’s) are of bone marrow origin, and able to differentiate into cartilage, blood vessel, fat, bone, and even muscle cells. MSC’s have migratory capabilities, traveling and seeking damaged tissue and inflammation, as well as promoting the transfer of host progenitor cells to these areas. These stem cells are active partakers in immunologic signaling enabling the secretion of molecules that orchestrate the immune and inflammatory responses, hence their “immunomodulatory” properties, which basically means that your body will not reject them or recognize them as foreign.

MSC’s were harvested from a young and healthy donor, selected from a pool of potential donors after rigorous testing and analysis. The adult stem cells were extracted from a single bone marrow biopsy and transferred to Stemedica’s expansion laboratories. After several passages, numerous cells were stored in liquid nitrogen at -160° C, and shipped to a designated clinical trial cell bank, where they lie dormant until needed.

Neural stem cells

Neural Stem Cells (NSC’s) originate from donated fetal neural tissue and are able to differentiate into most types of neural cells. Fetal tissue is considered adult stem cells which are very different to embryonic stem cells. They are widely accepted by religious institutions, including the Catholic Church. They are also migratory and able to guide resident stem cells toward the damaged or diseased tissue. They are thought to be migratory and may be capable of grafting and replacing damaged cells. It is also believed that the most important action lies on their neighboring effect on the host's cells coordinating their functions while secreting growth factors that are involved in neuroprotection and new cell formation.

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